Factors That Determine Sequence of Administration for Multiple Chemotherapeutic Agents

Chemotherapy agents are sometimes required to be administered in a specific sequence. What factors influence the need to follow a specific sequence?

—Name withheld on request

Multiple factors can influence the sequence of administration for chemotherapy drugs. Based on their mechanism of action, some drug combinations are more effective when given in a specific sequence; in other cases, this may also influence the toxicities of the chemotherapy regimen. Other considerations may be more practical, as in cases where it may be best to follow a certain order due to the risk of infusion reactions with the drugs being administered.